Showing posts with label lab panning. Show all posts
Showing posts with label lab panning. Show all posts

Sunday, June 18, 2017

Rigid Sided Anaerobic Glove Boxes - Theory of Design

Rigid anaerobic chamber glove box with airlock
Rigid construction anaerobic glove box with airlock
Courtesy Coy Lab Products
There are numerous threads of scientific research that require small environments with extremely low levels of oxygen. This anaerobic environment requires isolation from the surrounding atmosphere and a means to scavenge trace amounts of oxygen that inevitably get into the closed environment. It is also, in many cases, necessary to provide a means to transfer materials into and out of the chamber during use, as well as to allow operators to manipulate materials within the chamber.

One method applied to remove infiltrated oxygen is through the use of a catalyst within the chamber to react the oxygen with hydrogen, producing water vapor. This can be accomplished with a small fan enclosure that continuously or intermittently circulates chamber air across a palladium chloride coated alumina substrate. The palladium chloride supports the oxygen-hydrogen reaction, while the alumina substrate serves to absorb the water vapor. The fan must be properly sized and operated on a schedule that will treat the chamber atmosphere at a rate that is suitable for the application. Larger fan and catalyst combinations will produce larger turnover rates for the chamber atmosphere, along with faster recovery of anaerobic conditions.

For the movement of materials into and out of the work zone, an airlock is provided. The airlock enables isolation of the chamber interior work zone from the surrounding atmosphere and limits that amount of atmospheric air entering the chamber when materials are introduced to the anaerobic work zone. The capacity of the catalyst system is coordinated with the size of the airlock to provide rapid removal of the known quantity of oxygen introduced to the chamber each time the airlock is cycled.

Sealed glove ports provide an operator with the ability to hold and manipulate the contents of the chamber. Proper maintenance of the gloves and their mounting to the ports is essential to maintaining anaerobic conditions in the chamber. Because some degree of physical stress is placed on the glove mountings during normal use of the chamber, regular inspection of their seals is good practice.

Oxygen will diffuse into the chamber during normal operation. A source of hydrogen gas must be used to provide sufficient quantities to enable effective catalyst operation. A special gas mix can be used to purge the airlock that serves to reduce the oxygen level of the airlock and provides sufficient hydrogen to process the introduced oxygen, as well.

This is but a general description of how the system functions. Share your anaerobic process and research challenges with a product application specialist, combining your own process knowledge and experience with their product application expertise to develop the best solution for your application.

Monday, June 12, 2017

Technical Sales Representatives Add Value

chemical lab technician chemist
Equipment specialists can help lab and process operators
navigate to effective solutions
Laboratory equipment is often sold with the support of sales engineers working at the local or regional level. Realizing what these specialists have to contribute, taking advantage of their knowledge and talent, will help save time and cost and contribute to a better outcome when specifying, purchasing and installing laboratory equipment.

Consider these contributions:

Product Knowledge: Specialized sales engineers, by the nature of their job, have product knowledge that is both broad and deep. They are also current on new products, their capabilities and their proper application. Unlike information available on the Web, sales engineers can get advanced notice of product obsolescence and replacement options, new technologies coming to the market, and more. Also, because they are exposed to so many different types of applications and situations, sales engineers are a wealth of tacit knowledge that they readily share with their customers.

Experience: Whether a project engineer, lab manager, or researcher, you may be treading on fresh ground regarding many aspects of a major equipment purchase. You may not have a full grasp on how to handle a particular challenge presented by a project. Call in the technical sales rep - there can be real benefit in connecting to a source with past exposure to your current issue.

Access: Through a technical sales engineer, you may be able to look “behind the scenes” with a particular manufacturer and garner important information not publicly available. Sales reps deal with people, making connections between customers and manufacturer's support personnel that may not normally be public facing. They make it their business to know what’s going on with products, companies, and industries.

Of course, sales engineers will be biased. Any solutions proposed are likely to be based upon the products sold by the representative. But the best sales people will share the virtues of their products openly and honestly, and tell you when they do not have the right product for your application. This is where the discussion, consideration and evaluation of several solutions becomes part of achieving the best project outcome.

As a stakeholder in process or laboratory operation, it's highly recommended you develop a professional, mutually beneficial relationship with a laboratory and process equipment specialist, a problem solver. Look at a relationship with the local sales engineer as symbiotic. Their success, and your success, go hand-in-hand.

Monday, May 15, 2017

Environmental Chambers - Difference Between an Alarm and a Limit Control

walk-in controlled environment room
Walk-in Controlled Environment Room
Courtesy Percival Scientific
Users of controlled environment equipment are generally not process control experts. The user's interest in the equipment is, and should be, focused on how it furthers their own work and effort.

Lab equipment that provides a temperature control function will often have an integrated heating or cooling means that is regulated by the unit controller. Controlled environment chambers, including benchtop, floor standing, and walk-in types often are provided with sufficient heating of cooling capacity to do damage to the equipment, the contained product or work materials, even surrounding spaces if allowed to run out of control. Why so much power? Designing a chamber of any size to provide fast recovery after a disturbance, like a door opening, will boost the capacity requirements for the heating and cooling portions of the system. Similarly, equipment with extended temperature range is likely to have expanded cooling or heating, and there are many other performance requirements that have the same impact on the unit capacity. The key element for placing this type of equipment in an occupied space is how malfunction resulting in uncontrolled operation of the environmental conditioning system is handled to prevent catastrophe.

An alarm is an annunciation of an adverse condition. Alarm function may be, and often is, provided as part of the temperature controller, utilizing the same device, same sensor. Alarms tell the operator something has gone wrong, is about to go wrong, or is currently going wrong. The nature of most alarms allows the user to set the conditions at which notification occurs. Additionally, some equipment provides options for how alarms are handled. Audio and visual indication are common features, and some equipment is provided with alarm relay contacts that can be connected to building management systems or other remote monitoring equipment. Whether an alarm will automatically reset if proper conditions are restored, or manual intervention is required to stop any alarm related activity once the alarm has occurred can also be different ways in which alarm functions are implemented by manufacturers. The overall range of alarm functionality combinations is extensive, with some equipment providing richer feature sets than others.

Alarms, in some controlled environment systems, are configured to take some sort of action to remediate the adverse condition. This activity is separate from the announcement of the alarm condition. While having corrective action taken by the control system may seem advantageous, and in some cases it may help prevent loss or damage to product contained within the environmental chamber, this is not true limit control action and is not the best practice for assuring safe operation of machinery with the capacity to do real damage to itself or surrounding spaces.

A limit control may appear at the user interface level to mimic the function of an alarm. There is a difference, though. Properly done, a limit control operates with total independence from any part of the regular temperature controller. The limit controller will be a separate device and not share any operating hardware with the temperature controller device chain. What does this mean for the user?

Relying on the temperature controller to respond to an adverse condition has some potential flaws. The temperature controller, or any of the components in the temperature control device chain, could be the root cause of the adverse condition through malfunction or outright failure. Reliance on a control circuit, likely with a malfunction of one or more of its components, to prevent further temperature excursion is not good practice. A properly designed limit control circuit does not rely on any of the components in the potentially failed circuit to stop heating or cooling.

Not all failures are a single event. Chains of failure can trigger, or one failure can expose the existence of another system weakness or failure that was previously undetected. Having a positive and independent means to reliably stop system operation is not costly to implement and can head off catastrophes resulting in substantial loss of time and money. Catastrophe, for an environmental chamber, can look like this...
  • Freezing of product that should not be frozen
  • Freezing and bursting of pipes in a walk-in chamber
  • Destruction of work or product contained within a chamber due to excessively hot or cold temperatures
  • Excessively hot temperature that activates a fire protection sprinkler head in walk-in unit
In essence, the purpose of an environmental chamber is to create and maintain a single condition at any point in time. There is only one way that things can go right, and countless ways they can go wrong. Having an independent watchdog controller that prevents the worst from happening is good practice. Share your controlled environment chamber requirements and concerns with an application specialist. The combination of your process knowledge and experience with their product application expertise will yield an effective solution.

Friday, April 7, 2017

Atlantic Technology Group at Chesapeake Bay Chapter ISPE Conference

engineer speaking with customer about process equipment at showcase exhibit
Tim Holden, of Avant Garde Scientific, speaks with an attendee at the
2017 ISPE Chesapeake Bay Chapter Mid-Atlantic Life Sciences Showcase
Atlantic Technology Group continued its corporate sponsorship of the ISPE Chesapeake Bay Chapter this week at the 2017 Mid-Atlantic Life Sciences Showcase held at the University of Maryland Shady Grove Campus. In addition to the educational portion of the program, there was an evening get together with a keynote speaker and various exhibits of service and equipment vendors. It was a great opportunity for participants in various facets of the industry to come together in a casual environment and share ideas and experiences, and generally have a good time among others within their professional community.

ATG showcased technical aspects of their product offerings from:

  • Miele Professional - Specialized washing equipment for glass and plastic ware
  • Girton - cGMP washing equipment of standard and custom design
  • Elga - Point of  use water purification equipment
  • Esco - Biologial safety cabinets, specialty laminar air flow stations and equipment
  • BMT USA - cGMP sterilizers and ovens
On hand were David Jenkins, president of ATG, and Tim Holden from Avant Garde Scientific. Avant Garde sells and services the Atlantic Technology Group product offering in Maryland and the metro Washington, DC area.

A great organization, great event, very productive for everyone attending.

Monday, January 23, 2017

Conference and Trade Show Schedule for 2017

Atlantic Technology Group will be an active participant in a number of conferences and exhibitions in the life science industries throughout 2017. Their participation is part of a continuing effort to support the academic and trade organizations in the industries ATG serves. New product and application information, as well as the face to face exchange of viewpoints and ideas are a hallmark of these conferences. Review the schedule and make arrangements to attend one this year.

Reach out to Atlantic Technology Group for more information about registration or attendance at any of these events.
Pittcon Conference & Expo
March 5-9
Chicago, IL
Interphex
March 21-23
Javits Center, NYC
Mid-Atlantic Life Sciences Showcase
April 6

Life Sciences Technology Conference
March 14
Raleigh, NC



Laboratory Design Conference
April 24-26
Raleigh, NC

2017 Biomedical Research Equipment
and Supplies Exhibit

May 2
Ft. Detrick
Frederick, MD

In Vitro Biology Meeting
June 10-14
Raleigh, NC